June 08, 2009 - Advances in Sleep Research Help Speed Somnus Therapeutics’ Development of Zaleplon-Based Sleep-Maintenance Treatment - Research sponsored by Somnus Therapeutics, Inc. demonstrates that new controlled-release formulations of a marketed insomnia medication have shown a pharmacodynamic profile indicative of a potential therapy that could address a frequent complaint of insomnia sufferers: preventing middle-of-the-night (MOTN) awakening without next-morning hangover.Findings include specifically demonstrating that three controlled-release formulations produced maximum sedation 3 to 5 hours after administration with no residual effects observed after 8 hours. The studies applied technical advances in sleep monitoring to support clinical development and allow fine-tuning of dose and delivery during clinical studies, which may help bring an improved therapy to market more quickly and at a lower development cost.
The research, reported at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, LLC – a premier event for sleep research and sleep medicine professionals – was sponsored by Somnus Therapeutics, Inc. (“Somnus”), a private specialty pharmaceutical company that is developing controlled-release formulations of zaleplon to prevent MOTN awakening... [PDF] Somnus Therapeutics' Press Release -
